MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-type c) is a mitochondrial-derived peptide (MDP) – meaning it’s encoded in mitochondrial DNA, not nuclear DNA. This makes it part of a rare class of peptides that act as metabolic regulators directly tied to cellular energy production.

How it works:

Improves insulin sensitivity and glucose utilization Regulates metabolic pathways involved in fat oxidation and energy balance

Acts as an “exercise-mimetic”, increasing endurance and metabolic flexibility

Counters age-related metabolic decline, since natural MOTS-C levels fall with age

Supports stress resistance at the cellular level