KPV is one of the simplest but most potent anti-inflammatory research peptides – and the search

results back that up clearly.

KPV is a tripeptide made of Lysine-Proline-Valine. It’s a naturally occurring fragment of a-MSH

(alpha-melanocyte-stimulating hormone), but without the pigmentation effects of the parent

hormone.

This fragment retains a-MSH’s anti-inflammatory and immune-modulating power while avoiding

broader hormonal activity.

How it works:

Strong anti-inflammatory signaling via inhibition of NF-kB and other inflammatory pathways Immune

modulation without full immune suppression

Support for epithelial barrier integrity, especially in gut and skin research models

Reduction of cytokine activity (IL-6, TNF-α, etc.)

Wound-healing and tissue-repair support