Semax is one of the most extensively studied nootropic and neuroprotective peptides. Semax is a synthetic fragment of ACTH (adrenocorticotropic hormone) – specifically the ACTH(4-10) sequence – modified to remove hormonal activity while preserving and enhancing its neurological effects. It was originally developed in Russia for stroke recovery, cognitive impairment, and neuroprotection.

How it works:

Enhances cognitive performance (focus, memory, learning) Supports neuroprotection and brain repair pathways

Increases BDNF and other neurotrophic factors

Improves stress resilience without stimulant effects

Modulates neurotransmitters (dopamine, serotonin)

Does not affect cortisol, despite being ACTH-derive